I've now read several books on Kindle (the iPad app, not an actual Kindle) and enjoyed it all just fine. I occasionally get thrown momentarily, when flipping back and forth for a few pages, to find the layout of paragraphs or illustrations changing position, but I think that's just the nature of the beast. And I'm the odd man out here, because I'm usually very comfortable with Times New Roman.
Re BK's books: I read WELCOME TO MY WORLD on it before BK was shipping the hard copies, and it was fine. Two pages were wonky -- the acknowledgments and the list of musical numbers. I don't recall anything else. I also have RED GOLD -- which was actually my first Kindle book -- and even though I read the real book, I did flip through the Kindle version and don't recall anything unusual or amiss.
Otherwise, I've read THE MARTIAN, ASTRONAUTS WIVES CLUB, HELLRAISERS, and I'm in the middle of a large book by a music director, none of which have presented any problems or distractions.