I finished the first disc of GREY'S ANATOMY shows (5 episodes). Of those five, three were totally new to me, and terrific entertainment they were, too.
I do wonder why they've desaturated the color a bit out of the shows. Just slightly, but the credits are in full, richly saturated color and then the episodes are toned down a bit and are on the cool (blue) side of coloring.
Watching it each week in high definition, I hadn't noticed any desaturation, but it seems very noticeable to me with the DVDs.