I think the only thing interesting about Barnes and Noble are there discount remaindered books. Other than that it is another undisintinguished chain that carries only the best sellers and most popular and has limited variety. No different than a Borders or anywhere else. I've peculiar taste and the books I want to buy (those that aren't used), I can get through Amazon cheaper and easier. I miss the excitement of the hunt and browsing a bookstore, but the truth is, except for a few independents, they all carry the same stuff and it's all fairly mainstream.
The truly sad thing is the loss of the used bookstore, but I'm sure for most of those dealers, it's easier to go online without the overhead of maintaining a shop. With the demise of interesting book and record stores, shopping has sure gotten boring.