The Jason Bateman-Alec Mapa series was called SOME OF MY BEST FRIENDS, but one of its working titles had indeed been KISS ME GUIDO.
http://imdb.com/title/tt0259144/
The absolutely FUNNIEST moment in any TV sitcom I ever had the pleasure of witnessing came in "Some of My Best Friends."
Bateman had a straight guy in his apartment -- and he was a REALLY straight (just ask him, he's straight) man (this may have been the straight roomie, but given what follows, I'm not sure). Mapa's character was there, too. I don't remember the particulars of how well any of them know one another (except Bateman and Mapa are best friends), but a challenge was thrown down by the straight man, after a discussion about "fitness" and the fact that he was a fanatic about working out.
The scene, set in Bateman's living room, went something like this:
"Hit me!" the straight man said to Mapa as he tensed up his midsection in preparation for a solid punch.
"You don't wanna do this," Bateman's character said.
"Go on! Hit me! Trust me. I can take anything you throw at me" the straight man asserted.
Mapa sized him up, looked at Bateman, and then gave the straight man a very sharp slap across the face.
The straight man staggered and gave Bateman a "What the f***k!" look.
"What you have to understand is that he learned everything he knows about fighting from watching 'Dynasty'."
I laughed until I cried. And then I laughed some more.